1. Discrete microfluidics for the isolation of circulating tumor cell subpopulations targeting fibroblast activation protein alpha and epithelial cell adhesion molecule

    MA Witek, RD Aufforth, H Wang, JW Kamande, JM Jackson,...

    npj Precision Oncology 1 (1), 24

    DOI: 10.1038/s41698-017-0028-8

  2. Staphylococcus aureus extracellular vesicles (EVs): surface-binding antagonists of biofilm formation

    Im H, Lee S, Soper SA, Mitchell RJ.

    Mol Biosyst. 2017 Nov 21;13(12):2704-2714.

    DOI: 10.1039/c7mb00365j.

    PMID: 29104975

  3. Materials and microfluidics: enabling the efficient isolation and analysis of circulating tumour cells

    Jackson JM, Witek MA, Kamande JW, Soper SA.

    Chem Soc Rev. 2017 Jul 17;46(14):4245-4280.

    DOI: 10.1039/c7cs00016b. Review.

    PMID: 28632258

  4. Thermoplastic nanofluidic devices for biomedical applications

    Weerakoon-Ratnayake KM, O'Neil CE, Uba FI, Soper SA.

    Lab Chip. 2017 Jan 31;17(3):362-381.

    DOI: 10.1039/c6lc01173j. Review.

    PMID: 28009883

  5. 3D nanomolding and fluid mixing in micromixers with micro-patterned microchannel walls

    Bahador Farshchian, Alborz Amirsadeghi, Junseo Choi, Daniel S. Park, Namwon Kim, Sunggook Park

    Nano Converg. 2017 4:4

    DOI: 10.1186/s40580-017-0098-x

  6. The role of hydrophobic silane coating on Si stamps in nanoimprint lithography

    A Amirsadeghi, L Brumfield, J Choi, E Brown, JJ Lee, S Park

    J. Appl. Phys. 121 (4), 044909

    DOI: 10.1063/1.4974533

  7. CD15+ granulocyte and CD8+ T lymphocyte based gene expression clusters for ischemic stroke detection

    Adamski, Mateusz G. et al.

    Medical Research Archives, [S.l.], v. 5, n. 11, Nov. 2017.

    DOI: 10.18103/mra.v5i11.1597

  1. Thermoplastic nanofluidic devices for biomedical applications
    Kumuditha M. Weerakoon-Ratnayake Colleen E. O'Neil, Franklin I. Uba and Steven A. Soper
    Lab Chip, 2016, Advance Article
    DOI: 10.1039/C6LC01173J
  2. Characterization of activated cyclic olefin copolymer: effects of ethylene/norbornene content on the physiochemical properties
    Colleen E. O'Neil, Scott Taylor, Kumuditha Ratnayake, Swathi Pullagurla, Varshni Singh and Steven A. Soper
    Analyst, 2016,141, 6521-6532
    DOI: 10.1039/C6AN01448H
  3. Interrogating Surface Functional Group Heterogeneity of Activated Thermoplastics Using Super-Resolution Fluorescence Microscopy
    Colleen E. ONeil, Joshua M. Jackson, Sang-Hee Shim, and Steven A. Soper
    Anal. Chem., 2016, 88 (7), pp 3686–3696
    DOI: 10.1021/acs.analchem.5b04472
  4. Rapid Assessment of Minimal Residual Acute Myeloid Leukemia from Peripheral Blood Using a Microfluidic Chip
    Joshua M Jackson, James Taylor, Malgorzata Witek, Sally A Hunsucker, Jennifer Paulsen Waugh, Yuri D Fedoriw, Thomas C Shea, Steven A Soper, Paul M Armistead
    Blood, 2016, 126, 23, 1389
  5. Electrophoretic Separation of Single Particles Using Nanoscale Thermoplastic Columns
    Kumuditha Madushanka Weerakoon Ratnayake, Franklin I. Uba, Nyote J. Oliver-Calixte, Steven A. Soper
    Anal. Chem., 2016, 88 (7), pp 3569–3577
    DOI: 10.1021/acs.analchem.5b04065
  6. Microfluidics for the Detection of Minimal Residual Disease in Acute Myeloid Leukemia Patients using Circulating Leukemic Cells Selected from Blood
    Jackson JM, Taylor JB, Witek MA, Hunsucker SA, Waugh JP, Fedoriw Y, Shea TC, Soper SA, Armistead PM.
    Analyst. 2016, 21;141 (2):640-51.
    DOI: 10.1039/c5an01836f.
  7. Cancer: a global concern that demands new detection technologies.
    Analyst, 2016, 141, 367-370
    Steven A Soper, Avraham Rasooly
    DOI: 10.1039/C5AN90101D
  8. Improved clinical sensitivity detection of circulating tumor cell assays using a dual selection strategy in women with epithelial ovarian cancer
    W.Z. Wysham, M.A. Witek, S.A. Soper, V.L. Bae-Jump
    Gynecologic Oncology, 2016, vol 141, Supplement 1, 138
    DOI: http://dx.doi.org/10.1016/j.ygyno.2016.04.364
  9. Book Chapter in “Circulating Tumor Cells: Isolation and Analysis (John Wiley & Sons, Inc)
    Sinusoidal Microchannels with High Aspect Ratios for CTC Selection and Analysis
    Joshua M. Jackson, Małgorzata A. Witek, Steven A. Soper
    April 2016, 85-119
    DOI: 10.1002/9781119244554.ch4

1. Investigation of surface charge and electroosmostic flow in polymer nanoslits and nanochannels, F.I. Uba, S.R. Pullagurla, N. Sirasunthorn, J. Wu, S. Park, R. Chantiwas, Y. Cho, H. Shin and S.A. Soper, Analyst 140 (2015) 113-126.

2. High Process Yield Rates of Thermoplastic Nanofluidic Devices using a Hybrid Thermal Assembly Technique, Franklin I. Uba, Bo Hu, Kumuditha Weerakoon-Ratnayake, Nyote Oliver-Calixte, and S. A. Soper, LOC 15 (2015) 1038-1049. This appeared on the cover of the journal and has been a feature article in their BLOG.

3. Capture and Enzymatic Release of Circulating Tumor Cells, Soumya Nair, Joshua Jackson, Maggie Witek, V. Bae-Jump, P.A. Gehrig, W.Z. Wysham, P.M. Armistead, P. Voorhees and S.A. Soper, Chemical Communications 51 (2015) 3266-3269.

4. Current and Future Bioanalytical Approaches to Stroke Assessment, S. Pullagurla, A. Baird and S.A. Soper, Bioanalysis 7 (2015) 1017-1035.

5. Recent and Near-Future Advances in Nucleic Acid-based Diagnosis of Stroke, A.E. Baird, S.A. Soper, S. Pullagurla and M. Adamski, Expert Review of Molecular Diagnostics 5 (2015) 665-679.

6. Rapid Assessment of Minimal Residual Acute Myeloid Leukemia from Peripheral Blood Using a Microfluidic Chip, Jackson, JM, Taylor, J, Witek, M, Hunsucker, SA, Waugh, JP, Fedorw, YD, Shea, TC, Soper, SA, Armistead, PM, Blood 126 (2015) Dec. 3, 2015.

1. Solid-phase extraction and purification of membrane proteins using a UV-modified PMMA microfluidic Bioaffinity µSPE device, K. Battle, J.M. Jackson and S.A. Soper, Analyst, 139 (2014) 1355-1363.

2. Liquid-liquid segmented flows in polycarbonate microchannels with cross-sectional expansions, N. Kim, M.C. Murphy, S.A. Soper and D.E. Nikitopoulos, Int. J. Multiphase Flow, 58 (2014) 83-86.

3. Parallel affinity-based isolation of leukocyte subsets using microfluidics: Applications for stroke diagnosis, S.R. Pullagurla, M.A. Witek, J.M. Jackson, M.M. Lindell, M.L. Hupert, I.V. Nesterova, A.E. Baird and S.A. Soper, Anal. Chem. 86 (2014) 4058-4065.

4. Immobilization of lambda exonuclease onto polymer micropillar arrays for the solid-phase digestion of dsDNAs, N.J. Oliver-Calixte, F.I. Uba, K.N. Battle, K.M.W. Ratnayake and S.A. Soper, Anal. Chem. 86 (2014) 4447-4454.

5. Microfluidics for the analysis of membrane proteins: How do we get there? K.N. Battle, F.I. Uba and S.A. Soper, Electrophoresis (2014, accepted for publication).

6. Circulating tumor cells as a biomarker of response to treatment in patient-derived xenograft mouse models of pancreatic adenocarcinoma, Trophy, R.J., Tignanelli, C.J., Kamande, J.W., R.A. Moffitt, S.G. Herrera Loeza, S.A. Soper, J.J. Yen, PLOS ONE 9 (2014) e89474.

7. Next generation qPCR and validation of stroke-related whole blood gene expression, A.G. Mateusz, L.E. Yan, Wagner, C. Seales-Bailey, H. Yu, S.A. Soper, Murphy, M.C., A.E. Baird, Annals of Neurology 74 (2014) S16.

1. The expression of individual genes in acute stroke differs across leukocyte subsets, A.G. Mateusz, E. Wagner, Y. Li, H. Yu, S.A. Soper and A.E. Baird, Annals of Neurology, 72 (2013) S1.

2. Simultaneous detection of 10 K-ras mutations by free-solution conjugate electrophoresis of ligase detection reaction products on glass microchips, J. Albrecht, A. Kotani, J. Lin, S.A. Soper and A.E. Barron, Electrophoresis 34 (2013) 590-597.

3. Identification of Methicillin-resistant Staphylococcus aureus using an integrated and modular microfluidic system, H.W. Chen, H. Wong, M. Hupert, S.A. Soper, Analyst 138 (2013) 1075-1083.

4. Influence of material transition and interfacial area changes on flow and concentration in electro-osmosis flows, S.D. Rani, B.-Y. You, S.A. Soper, M.C. Murphy, D.E. Nikitopoulos, Anal. Chimica Acta 770 (2013) 103-110.

5. Next generation qPCR for the high throughput measurement of gene expression in multiple leukocyte subsets, M. Adamski, Y. Li, E. Wagner, H.Yu, C. Seales-Bailey, S.A. Soper, M.C. Murphy and A. Baird, J. Biomolecular Screening 18 (2013) 1008-1017.

6. Single-molecule FRET: An approach for quantitative expression profiling of low copy number transcripts in near real-time, Z.Y. Peng, B. Young, A.E. Baird and S.A. Soper, Anal. Chem. 85 (2013) 7851-7858.

7. UV modification of polymeric high aspect ratio microstructures: Ramifications in antibody surface loading for circulating tumor cell selection, J. M. Jackson, M. A. Witek, M. L. Hupert, C. Brady, J. J. Yeh and S. A. Soper, Lab Chip 14 (2014) 106-117.

8. Modular microfluidic system for the high throughput selection, enumeration and phenotyping of circulating tumor cells, J. Kamande, H. Wang, J.J. Yeh, M.L. Hupert and S.A. Soper, Anal. Chem. 85 (2013) 9092-9100.

9. Nanostructure shape effects on response of plasmonic aptamer sensors, B. Subramanian, K.M. Mayer, S. Lee, S.A. Soper, J.H. Hafner and D.A. Spivak, J. Molc. Recogn. 26 (2013) 402-407.

10. Circulating tumor cells as a possible marker for micrometastatic disease in patients with localized pancreatic cancer, R.D. Aufforth, J.J. Baker, M.A. Witek, J.W. Kamande, H.J. Kim, P. Kuan, S.A. Soper and J.J. Yeh, Annals of Surgical Oncology, 20 (2013) S129.

11. Distinguishing single DNA nucleotides based on their times of flight through nanoslits: A molecular dynamics simulation study, B. Novak, D. Moldovan, D.E. Nikitopoulos, and S.A. Soper, J. Phys. Chem. B, 117 (2013) 3271-3279.

12. H. Kim, S.A. Soper and E.J. Podlaha-Murphy, ECS Transactions, 53 (2013) 9-14.

13. Modeling of misalignment effects in microfluidic interconnects for modular bio-analytical chip applications, S.D. Rani, T. Park, B.H. You, S.A. Soper, M.C. Murphy and D.E. Nikitopoulos, Electrophoresis, 34 (2013) 2988-2995.

14. Circulating tumor cells as a biomarker of response to treatment in patient derived xenograft mouse models of pancreatic adenocarcinoma, R.J. Torphy, C.J. Tignanelli, R.A. Moffitt, S.A. Soper, J.J. Yeh, J. Am. College Surgeons, 217 (2013) S30.

15. LED-induced in-column molecular imprinting for solid phase extraction/capillary electrophoresis, X. Zhang, S. Zu, Y.I. Lee, and S.A. Soper, Analyst, 138 (2013) 2821-2824.

16. Arrays of high-aspect ratio microchannels for high-throughput isolation of circulating tumor cells, M.L. Hupert, J.M. Jackson, H. Wang, M.A. Witek, J. Kamande, M.I. Milowsky, Y.E. Whang and S.A. Soper, Microsyst. Technol. (2013; DOI 10.1007/s00542-013-1941-6).

1. Ultra-sensitive affinity chromatography on avidin-functionalized PMMA microchip for low abundant post-translational modified protein enrichment, H. Xia, K.K. Murray, S.A. Soper, J. Feng, Biomed. Microdev. 14 (2012) 67-81.

2. Enriching carbonylated proteins inside a microchip through the use of oxalyldihydrazide as a crosslinker, B.C. Hollins, S.A. Soper, J. Feng, Lab on a Chip, 12 (2012) 2526-2532.

3. Fully Integrated Thermoplastic Genosensor for the Highly Sensitive Detection and Identification of Multi-Drug-Resistant Tuberculosis, H. Wang, H.W. Chen, M.L. Hupert, P.C. Chen, P. Datta, T.L. Pittman, J. Goettert, M.C. Murphy, D. Williams, F. Barany, S.A. Soper, Angewandte Chemie, Int. Ed. 51 (2012) 4349-4353.

4. Hydrodynamic shearing of DNA in a polymeric microfluidic device, I.V. Nesterova, M.L. Hupert, W.A. Witek, S.A. Soper, Lab Chip, 12 (2012) 1044-1047.

5. Modular Microfluidic System Fabricated in Thermoplastics for the Strain-Specific Detection of Bacterial Pathogens, H.W. Chen, H. Wong, M. Hupert, S.A. Soper, Lab Chip 12 (2012) 3348-3355.

6. Design and development of a field-deployable single-molecule detector (SMD) for the analysis of molecular markers, J.M. Emory, Z.Y. Peng, B. Young, M.L. Hupert, A. Rousselet, D. Patterson, B. Ellison, S.A. Soper, Analyst, 137 (2012) 87-97.

7. EndoV/DNA ligase mutation scanning assay using microchip capillary electrophoresis and dual-color laser-induced fluorescence detection, A. Kotani, M.A. Witek, J.K. Osiri, H. Wang, R. Sinville, H. Pincas, F. Barany, S.A. Soper, Anal. Methods, 4 (2012) 58-64.

8. Ultra-sensitive affinity chromatography on avidin-functionalized PMMA microchip for low abundant post-translational modified protein enrichment, H. Xia, K.K. Murray, S.A. Soper and June Feng, Biomedical Microdevices 14 (2012) 67-81.

9. Two-dimensional nitrosylated protein fingerprinting by using poly (methyl methacrylate) microchips, S.Y. Wang, S.K. Njoroge, K. Battle, C. Zhang, B.C. Hollins, S.A. Soper and June Feng, Lab Chip 12 (2012) 3362-3369.

10. Enriching carbonylated proteins inside a microchip through the use of oxalyldihydrazide as a crosslinker, B.C. Hollins, S.A. Soper and J. Feng, Lab Chip 12 (2012) 2526-2532.

1. Near-IR Single Fluorophore Quenching System Based on Phthalocyanine Aggregation and its Application for High Throughput Screening (HTS) Assays, I. V. Nesterova, C. A. Bennett, S. S. Erdem, R. P. Hammer, P. L. Deininger, and S. A. Soper, Analyst 136 (2011) 1103-1105.

2. Fabrication and Applications of Polymer Nanochannels and Nanoslits, R. Chantiwas, S. Park, S.A. Soper, B.L. Kim, S. Takayama, V. Sunkara, H. Hwang, Y.K. Cho, Chem. Soc. Rev. 40 (2011) 3677-3702.

3. High-throughput Selection, Enumeration, Electrokinetic Manipulation, and Molecular Profiling of Low-Abundance Circulating Tumor Cells. U. Dharmisiri, S.A. Soper, Anal. Chem. 83 (2011) 2301-2309.

4. Simple and Instantaneous Room Temperature Bonding of Thermoplastics and Poly(dimethyl siloxane), V. Sunkara, D.K. Park, H. Hwang, R. Chantiwas, S.A. Soper and Y.K. Cho, Lab Chip 11 (2011) 962-965.

5. Solid-Phase Bioreactor with Continuous Sample Deposition for Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry, J. Lee, S.A. Soper, and K.K. Murray, Rap. Comm. Mass Spectrometry 25 (2011) 693-699.

6. Gas-liquid Two-phase Flows in Rectangular polymer microchannels, N. Kim, E. Evans, D. Park, S.A. Soper, M.C. Murphy and D. Nikitopoulos, Exp. Fluids 51 (2011) 373-393.

7. Surface Modification of Droplet Polymeric Microfluidic Devices for the Stable and Continuous Generation of Aqueous Droplets, S. Balamurugan, N. Kim, W. Lee, D.A. Spivak, D. Nikitopoulos, R.L. McCarley, and S.A. Soper, Langmuir 27 (2011) 7949-7957.

8. A vertically-stacked, polymer, microfluidic PCR/ExoSAP-IT®/LDR analyzer: High accuracy detection of low-abundance K-ras point mutations, K. Han, T.Y. Lee, M.C. Murphy, D.E. Nikitopoulos, S.A. Soper, and M.A. Batzer, Anal. Biochem. 417 (2011) 211-219.

9. Complete plastic nanofluidic devices for DNA analysis via direct imprinting with polymer stamps, J. Wu, R. Chantiwas, A. Amirsadeghi, S.A. Soper, and S. Park, Lab on a Chip 11 (2011) 2984-2989.

10. Integrated Modular Microfluidic System with CFPCR and Affinity Purification of the Resulting Products, S. Njoroge, M. Witek and S.A. Soper, Electrophoresis 32 (2011) 3221-3232.

1. Single-Pair Fluorescence Resonance Energy Transfer (spFRET) for the High Sensitivity Analysis of Low Abundant Proteins using Apatamers as Molecular Recognition Elements. W. Lee, A. Obubuafo, Y. Lee, and S.A. Soper, J. Fluoresc. 20 (2010) 203-213.

2. Fabrication of a Cyclic Olefin Copolymer Waveguide for Evanescence Excitation. P.I. Okagbare, J.M. Emory, P. Datta, J. Goettert and S.A. Soper. Lap Chip 10 (2010) 66-73.

3. Fabrication and Mathematical Analysis of an Electrochemical Microactuator (ECM) Using Electrodes Coated with Platinum Nano-particles. D.E. Lee, S.A. Soper, W.J. Wang, Microsystem Technologies-Micro-and Nanosystems-Information Storage and Processing Systems 16 (2010) 381-390.

4. Cross-Talk Free Dual-Color Fluorescence Cross-Correlation Spectroscopy (FCCS) for the Study of Enzyme Activity, W. Lee Y.-Ill Lee, J. Lee, L. M. Davis, P. Deininger, and S. A. Soper, Anal. Chem. 82 (2010) 1401-1410.

5. Thermoswitchable Electrokinetic Ion-Enrichment/Elution Based on a Poly(N-isopropylacrylamide Hydrogel Plug in a Microchannel, Z. Li, Q. He, D. Ma, H.W. Chen, S.A. Soper, Anal. Chem. 82 (2010) 10030-10036.

6. Enrichment and Detection of Escherichia coli O157:H7 from Water Samples Using an Antibody Modified Microfluidic Chip, U. Dharmasiri, M. A. Witek, A. A. Adams, J. K. Osiri, M. L. Hupert, T. S. Bianchi, D. L. Roelke, and S. A. Soper, Anal. Chem. 82 (2010) 2844-2849.

7. Microsystems for the Capture of Low Abundant Cells, U. Dharmasiri, A.A. Adams, M. Witek and S.A. Soper, Annual Reviews in Analytical Chemistry 3 (2010) 409-431.

8. Ligase Detection Reaction Generation of Molecular Beacons for the Real-Time Analysis of Bacterial Pathogens using Single-Pair FRET, Z. Pang and S.A. Soper, Anal. Chem. 82 (2010) 9727-9735.

9. Polymer-based Dense Fluidic Network for High Throughput Screening with Ultrasensitive Fluorescence Detection, P.I. Okagbare and S.A. Soper, Electrophoresis 31 (2010) 3074-3082.

10. Titer-plate formatted continuous flow thermal reactors: Design and performance of a nanoliter reactor, P.C. Chen, D.S. Park, B.H. You, N. Kim, T. Park, S.A. Soper, D.E. Nikitopoulos, and M.C. Murphy, Sens. Act. B 149 (2010) 291-300.

11. Ultra-fast Two-Dimensional Microchip Electrophoresis using SDS-PAGE and Microemulsion Electrokinetic Chromatography for Protein Profiling, J. Osiri, H. Shadpour and S.A. Soper, Anal. Bioanal. Chem. 398 (2010) 489-498.

12. Microchip Electrophoresis of Alu Elements for Gender Determination and Inference of Human Ethnic Origin, S.K. Njoroge, M.K. Witek, M.L. Hupert, S.A. Soper, Electrophoresis 31 (2010) 981-990.

13. Titer-plate Formatted Continuous Flow Thermal Reactors for High Throughput Applications, D. Park, P.-C. Chen, B.H. You, N. Kim, T. Park, T.Y. Lee, P. Datta, Y. Desta, S.A. Soper, D.E. Nikitopoulos, M.C. Murphy, J. Micromechn. Microeng. 20 (2010) 055003.

14. Simple Fabrication Methods for Producing 1D Nanoslits in Thermoplastics and the Transport Dynamics of Double-Stranded DNA through these Slits, R. Chantiwas, M. Hupert, S. Park, P. Datta, J. Goettert, Y.-K. Cho, and S. A. Soper, Lab on a Chip 10 (2010) 3255-3264.

15. Assessment of Glycoprotein Interactions with 4-[(2-aminoethyl)carbamoyl]phenylboronic Acid Surfaces using Surface Plasmon Resonance Spectroscopy, D. Guzman, J. Macalindong, S.A. Soper, and R.L. McCarley, Anal. Chem. 82 (2010) 8970-8977.


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